Islet transplantation is a promising therapy for patients with type 1 diabetes that can provide moment-to-moment metabolic\r\ncontrol of glucose and allow them to achieve insulin independence. However, two major problems need to be overcome: (1)\r\ndetrimental immune responses, including inflammation induced by the islet isolation/transplantation procedure, recurrence\r\nautoimmunity, and allorejection, can cause graft loss and (2) inadequate numbers of organ donors. Several gene therapy\r\napproaches and pharmaceutical treatments have been demonstrated to prolong the survival of pancreatic islet grafts in animal\r\nmodels; however, the clinical applications need to be investigated further. In addition, for an alternative source of pancreatic �Ÿ-cell\r\nreplacement therapy, the ex vivo generation of insulin-secreting cells from diverse origins of stem/progenitor cells has become an\r\nattractive option in regenerative medicine. This paper focuses on the genetic manipulation of islets during transplantation therapy\r\nand summarizes current strategies to obtain functional insulin-secreting cells from stem/progenitor cells
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